A1612

AF-353 hydrochloride

≥98% (HPLC), powder

• Synonym(e): 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride, Ro 4 hydrochloride
• Empirische Formel (Hill-System): C₁₄H₁₇IN₄O₂ · HCl
• CAS-Nummer: 927887-18-1
• Molekulargewicht: 436.68
• UNSPSC Code: 12352203

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: off-white to light brown
• solubility: DMSO: >10 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: Cl.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I

Beschreibung

Biochem/physiol Actions

AF-353 is a P2X3, P2X2/3 antagonist.

AF-353 is a potent antagonist of P2X3 homotrimers and P2X2/3 heterotrimers with a pIC50 range of 7.3 - 8.5. The compound does not affect other P2X family members at 300-fold excess concentrations. AF-353 significantly reversed pain behavior in a rat model of bone cancer pain.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable