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Merck

90190

Sigma-Aldrich

Transferrin aus menschlichem Blutplasma

≥95% (GE)

Synonym(e):

Human Transferrin, Siderophilin

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About This Item

CAS-Nummer:
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202
NACRES:
NA.61

Biologische Quelle

human plasma

Assay

≥95% (GE)

Form

powder or crystals

Mol-Gew.

Mr ~79550

Methode(n)

tissue culture: suitable

Verunreinigungen

≤0.01% iron traces (AAS)

Löslichkeit

H2O: 50 mg/mL, clear, colorless to faintly yellow or pink

UniProt-Hinterlegungsnummer

Lagertemp.

2-8°C

Angaben zum Gen

human ... TF(7018)

Anwendung

Transferrin is an important supplement in serum-free tissue culture media.

Biochem./physiol. Wirkung

Transferrin is glycoprotein, approx. 80 kDa, with two binding sites for iron. It transports iron from its primary store in the liver to tissues that require iron, primarily bone marrow and spleen, but also brain. It binds Fe3+ extremely tightly (Kdiss 10-30 to 10-27), protecting against oxidant effects of free plasma iron.

Sonstige Hinweise

Review: Iron transport and storage

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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U R Goonetilleke et al.
mBio, 3(2) (2012-03-15)
Pneumococcal meningitis can lead to death or serious neurological sequelae as a result of the host inflammatory response. We investigated the association between host response protein expression and outcome in patients with pneumococcal meningitis. Cerebrospinal fluid (CSF) was obtained from
B. Gorinsky
Adv. Red Blood Cell Biol., D.J. Weatherall et al., eds., 7-7 (1981)
Iron transport and storage.
R R Crichton et al.
European journal of biochemistry, 164(3), 485-506 (1987-05-04)
Melissa Pynnonen et al.
PLoS pathogens, 7(7), e1002104-e1002104 (2011-07-14)
Staphylococcus aureus nasal colonization is an important risk factor for community and nosocomial infection. Despite the importance of S. aureus to human health, molecular mechanisms and host factors influencing nasal colonization are not well understood. To identify host factors contributing
Jieru E Lin et al.
Cancer research, 76(2), 339-346 (2016-01-17)
Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs

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