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85976

Sigma-Aldrich

Methoxypolyethylenglykol succinat-N-succinimidylester

5,000, ≥90%

Synonym(e):

O-Methyl-O′-succinylpolyethylenglykol 5′000 N-succinimidylester, PEG-succinimidyl-succinat, mono-Methyl-polyethylenglykol 5′000 succinat-N-succinimidylester

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About This Item

CAS-Nummer:
78274-32-5
MDL-Nummer:
MFCD00131598
UNSPSC-Code:
12162002
PubChem Substanz-ID:
57653073
NACRES:
NA.25

Assay

≥90%

Form

powder

Lagertemp.

−20°C

InChI

1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2

InChIKey

OVPTZXRXNNJKSJ-UHFFFAOYSA-N

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Anwendung


  • Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. This study explores the use of Methoxypolyethylene glycol succinate N-hydroxysuccinimide (MPEG-S-NHS) for creating peptide-conjugated polymer micelles that are sensitive to matrix metalloproteinases-2/9. These micelles are designed for site-specific drug release and increased tumor targeting, showcasing a promising application in advanced drug delivery systems (Zhang X, Wang X, Zhong W, Ren X, Sha X, Fang X, 2016) [link].


Verlinkung

Shearwater Polymers Produkt

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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H Matsuyama et al.
Chemical & pharmaceutical bulletin, 39(3), 743-746 (1991-03-01)
Phospholipase D from Streptomyces sp. AA586, PLDP, was modified with methoxypolyethylene glycol succinimidylsuccinate (ss-PEG), an active derivative of polyethylene glycol. By titration with trinitrobenzene sulfonate (TNBS), approximately 70% of the free amino groups in the enzyme protein were shown to
G Sirokmán et al.
Protein science : a publication of the Protein Society, 2(7), 1161-1170 (1993-07-01)
Bacteriorhodopsin (BR), from the purple membrane (PM) of Halobacterium halobium, was chemically modified with methoxypolyethylene glycol (m-PEG; molecular weight = 5,000 Da) succinimidyl carbonate. The polyethylene glycol-bacteriorhodopsin (m-PEG-SC-BR33) conjugate, containing one polyethylene glycol chain, was water soluble. The secondary structure
Y P Li et al.
Acta pharmacologica Sinica, 22(6), 549-555 (2001-12-19)
To assess the merits of polyethylene glycol-modified recombinant human tumor necrosis factor alpha (PEG-rHuTNF-alpha). The rHuTNF-alpha was modified with N-succinimidyl succinate monomethoxy polyethylene glycol (SS-PEG) of three different molecular weights. The PEG-rHuTNF-alpha was separated into fractions of various molecular weights
M A Croyle et al.
Journal of virology, 75(10), 4792-4801 (2001-04-20)
Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors. First-generation viruses with E1a and E1b deleted are limited by transient expression of the transgene and substantial inflammatory responses. Gene transfer is also significantly curtailed
M S Hershfield et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(16), 7185-7189 (1991-08-15)
Modification by covalent attachment of polyethylene glycol (PEG) can reduce the immunogenicity and prolong the circulating life of proteins, but the utility of this approach for any protein is restricted by the number and distribution of PEG attachment sites (e.g.
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