70485

Naphthol-AS-E-Phosphat

suitable for histology

• Synonym(e): KG-501
• Empirische Formel (Hill-System): C₁₇H₁₃ClNO₅P
• CAS-Nummer: 18228-17-6
• Molekulargewicht: 377.72
• UNSPSC Code: 12352204
• NACRES: NA.83
• PubChem Substance ID: 329762485
• EC Number: 242-106-1
• Beilstein/REAXYS Number: 6664478
• MDL number: MFCD00042718

Eigenschaften

• assay: ≥80% (HPLC)
• Quality Segment: 100
• form: powder
• application(s): histology
• storage temp.: 2-8°C
• SMILES string: OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
• InChI: 1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
• InChI key: RQAQWBFHPMSXKR-UHFFFAOYSA-N

Beschreibung

Application

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

Biochem/physiol Actions

Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.

Other Notes

Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)