Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that produce growth factor c-Kit ligand (Kitl/SCF) and chemokine CXCL12, and were
Amido derivatives 10-18 of the corresponding oxyamines were synthesised as melatoninergic ligands by the reaction of hydroxyphtalimide with the halogeno derivatives or the corresponding alcohols using Mitsunobu reaction conditions. The affinity of the compounds for chicken brain melatonin receptors and
Chromatographic separation of an ethanolic extract of rhizomes of Asphodelus tenuifolius Cav. (Asphodelaceae) yielded in addition to beta-sitosterol, stigmasterol and two anthraquinone derivatives, 1,8-dimethoxynaphthalene as well as two new naphthalene derivatives. The new compounds were identified as 2-acetyl-8-methoxy-3-methyl-1-naphthol and 2-acetyl-1,8-dimethoxy-3-methylnaphthalene.
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