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Merck

327R-1

Sigma-Aldrich

PSMA (EP192) Rabbit Monoclonal Primary Antibody

Synonym(e):

Prostate-specific membrane antigen

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203

Biologische Quelle

rabbit

Qualitätsniveau

100
500

Konjugat

unconjugated

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

EP192, monoclonal

Beschreibung

For In Vitro Diagnostic Use in Select Regions

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

vial of 0.1 mL concentrate (327R-14)
vial of 0.1 mL concentrate Research Use Only (327R-14-RUO)
vial of 0.5 mL concentrate (327R-15)
vial of 1.0 mL concentrate (327R-16)
vial of 1.0 mL concentrate Research Use Only (327R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (327R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (327R-17)
vial of 7.0 mL pre-dilute ready-to-use (327R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (327R-18-RUO)

Hersteller/Markenname

Cell Marque

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:40 (concentrated)

Isotyp

IgG

Kontrolle

prostate

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

cytoplasmic, membranous

Angaben zum Gen

human ... FOLH1(2346)

Allgemeine Beschreibung

Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein with enzymatic activity. PSMA is expressed in normal prostate epithelial cells as well as prostate neoplastic cells. It has been demonstrated that PSMA expression is increased in prostate cancer and is correlated with disease progression. Although highly sensitive and specific for prostate, PSMA also labels a subset of non-prostate tissues, including the small intestine and kidney. PSMA is useful for identifying metastatic prostate carcinoma and distinguishing prostate carcinoma from urothelial carcinoma.

Qualität


IVD

IVD

IVD

RUO

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Arundhati Ghosh et al.
Journal of cellular biochemistry, 91(3), 528-539 (2004-02-03)
Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression
Woo Jin Oh et al.
Journal of pathology and translational medicine, 50(5), 345-354 (2016-08-09)
The pathologic distinction between high-grade prostate adenocarcinoma (PAC) involving the urinary bladder and high-grade urothelial carcinoma (UC) infiltrating the prostate can be difficult. However, making this distinction is clinically important because of the different treatment modalities for these two entities.
Sam S Chang
Reviews in urology, 6 Suppl 10, S13-S18 (2006-09-21)
Efforts to evaluate and discover diagnostic and therapeutic markers for prostate cancer continue. One of these, prostate-specific membrane antigen (PSMA), a transmembrane protein expressed in all types of prostatic tissue, remains a useful diagnostic and possibly therapeutic target. The radio-immunoconjugate
Kurt D Bernacki et al.
Diagnostic cytopathology, 42(7), 570-575 (2013-11-26)
The diagnosis of metastatic prostate carcinoma frequently requires the use of immunohistochemical adjuncts. Immunohistochemistry for prostate-specific antigen (PSA) is commonly used for this purpose but can be of limited utility. Recently, prostate-specific membrane antigen (PSMA) has been shown to be
D A Silver et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 3(1), 81-85 (1997-01-01)
Prostate-specific membrane antigen is a type II membrane protein with folate hydrolase activity produced by prostatic epithelium. The expression of this molecule has also been documented in extraprostatic tissues, including small bowel and brain. In the present study, an extensive

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