26740

Cholesterin

from lanolin, ≥95.0% (GC)

• Synonym(e): 3β-Hydroxy-5-cholesten, 5-Cholesten-3β-ol
• Empirische Formel (Hill-System): C₂₇H₄₆O
• CAS-Nummer: 57-88-5
• Molekulargewicht: 386.65
• UNSPSC Code: 12352200
• PubChem Substance ID: 57648186
• eCl@ss: 39023139
• EC Number: 200-353-2
• Beilstein/REAXYS Number: 1915888
• MDL number: MFCD00003646

Eigenschaften

• biological source: lanolin
• assay: ≥95.0% (GC)
• form: powder with small lumps
• optical activity: [α]20/D −36±2°, c = 2% in dioxane
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.), 147-150 °C
• density: 1.067 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Gene Information: human ... POLA1(5422), TOP2A(7153) ; rat ... Ar(24208), Polb(29240)

Beschreibung

Application

Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

Biochem/physiol Actions

Hauptbestandteil biologischer Membranen; ca. 25% des gesamten Lipids im Gehirn ist Cholesterin.

Cholesterol is a lipid makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)