19176

DL-Buthionin-sulfoximin

≥99.0% (TLC)

• Synonym(e): DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine
• Empirische Formel (Hill-System): C₈H₁₈N₂O₃S
• CAS-Nummer: 5072-26-4
• Molekulargewicht: 222.31
• Beilstein: 2367136
• MDL-Nummer: MFCD00070309
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 57647786
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Assay: ≥99.0% (TLC)
• Form: powder or crystals
• mp (Schmelzpunkt): 215 °C
• Löslichkeit: H₂O: 50 mg/mL, clear to almost clear, colorless
• Lagertemp.: 2-8°C
• SMILES String: CCCCS(=N)(=O)CCC(N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
• InChIKey: KJQFBVYMGADDTQ-UHFFFAOYSA-N

Beschreibung

Anwendung

DL-Buthionine-sulfoximine is suitable for use to:

• examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
• investigate the effect of BSO on development of bovine embryos
• inhibit GSH in several studies
• investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Biochem./physiol. Wirkung

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

Sonstige Hinweise

Depletes glutathionine in isolated cells

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves