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Y0000154

Tolfenaminsäure

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

2 (3-Chlor-2-methylanilino)-benzoesäure, 2 (3-Chlor-2-methylphenylamino)-benzoesäure

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About This Item

Empirische Formel (Hill-System):
C14H12ClNO2
CAS-Nummer:
13710-19-5
Molekulargewicht:
261.70
MDL-Nummer:
MFCD00133865
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329830867
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

tolfenamic acid

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

Cc1c(Cl)cccc1Nc2ccccc2C(O)=O

InChI

1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

InChIKey

YEZNLOUZAIOMLT-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Tolfenamic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Nicht-steroides entzündungshemmendes Mittel.. Beeinträchtigt die Synthese von β-Amyloid-Precursor-Protein und damit Aβ-Peptide, durch die Förderung des Abbaus eines wesentlichen Transkriptionsfaktors.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Die Dokumentenbibliothek aufrufen

H Isomäki
Pharmacology & toxicology, 75 Suppl 2, 64-65 (1994-01-01)
Tolfenamic acid (TA) is an interesting drug for the treatment of rheumatic diseases because of its capacity to inhibit the synthesis of leukotrienes. It may have fewer upper gastrointestinal side effects than other NSAIDs which inhibit only the synthesis of
Tolfenamic acid and leukotriene synthesis inhibition.
E Moilanen et al.
Pharmacology & toxicology, 75 Suppl 2, 60-63 (1994-01-01)
Riyaz Basha et al.
Frontiers in bioscience (Scholar edition), 3, 797-805 (2011-01-05)
Non-steroidal anti-inflammatory drugs (NSAIDs) are primarily used for the treatment of acute or chronic conditions with pain and inflammation. Evidence from a wide range of sources suggested that chronic administration of NSAIDs reduced the risk of cancer incidences. Both the
P E Hansen
Pharmacology & toxicology, 75 Suppl 2, 81-82 (1994-01-01)
The possible role of prostaglandins (PGs) in migraine has been the subject of increasing attention after the rather dramatic experiments done in man by Bergström and coworkers more than 25 years ago (1965). The role of PGs in migraine, however
Gastrointestinal tolerance studies on tolfenamic acid in humans and animals.
O Eskerod
Pharmacology & toxicology, 75 Suppl 2, 44-48 (1994-01-01)
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