BP1083

Isoniazid

British Pharmacopoeia (BP) Reference Standard

• Synonym(e): 4-Pyridincarbonsäurehydrazid, INH, Isonicotinsäurehydrazid
• Empirische Formel (Hill-System): C₆H₇N₃O
• CAS-Nummer: 54-85-3
• Molekulargewicht: 137.14
• NACRES: NA.24
• UNSPSC Code: 41116107
• Beilstein/REAXYS Number: 119374
• MDL number: MFCD00006426

Eigenschaften

• grade: pharmaceutical primary standard
• API family: isoniazid
• form: powder
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• mp: 171-173 °C (lit.)
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• storage temp.: 2-8°C
• SMILES string: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• InChI key: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isoniazid BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Isoniazid Oral Solution

Biochem/physiol Actions

Antibiotikum für die Behandlung von Mycobacterium tuberculosis; inhibiert die Mycolsäure-Biosynthese. Wird von hepatischer N-Acetyltransferase (NAT) und Cytochrom P450 2E1 (CYP2E1) zu Hepatotoxinen metabolisert. Induziert selektiv die Expression von CYP2E1. Inhibiert Aktivitäten von CYP2C19 und CYP3A4 reversibel und inaktiviert CYP1A2, CYP2A6, CYP2C19 und CYP3A4 bei klinisch relevanten Konzentrationen.

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Oral - Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3