PC420
Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb
liquid, Calbiochem®
Synonym(e):
Anti-Vanilloid Receptor
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Alle Fotos(1)
About This Item
UNSPSC-Code:
12352203
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
purified antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
liquid
Enthält
≤0.1% sodium azide as preservative
Speziesreaktivität
rat, mouse
Hersteller/Markenname
Calbiochem®
Lagerbedingungen
OK to freeze
avoid repeated freeze/thaw cycles
Isotyp
IgG
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
mouse ... Trpv1(193034)
Allgemeine Beschreibung
Anti-Capsaicin Receptor (Ab-1) (824-838), rabbit polyclonal, recognizes the ~100 kDa capsaicin receptor in mouse spinal cord extract. It is validated for WB, IF & IHC in frozen and paraffin sections.
Protein A purified rabbit polyclonal antibody. Recognizes the ~100 kDa capsaicin receptor protein.
Recognizes the ~100 kDa capsaicin receptor protein in mouse spinal cord extract.
Immunogen
a synthetic peptide (EDAEVFKDSMVPGEK) corresponding to amino acids 824-838 of rat capsaicin receptor, conjugated to KLH
Anwendung
Frozen Sections (5 g/ml, see application references)
Immunoblotting (5-10 g/ml)
Immunofluorescence (2 g/ml)
Paraffin Sections (5 g/ml; no pre-treatment required)
Verpackung
Please refer to vial label for lot-specific concentration.
Warnhinweis
Toxicity: Standard Handling (A)
Hinweis zur Analyse
Positive Control
Mouse spinal cord dorsal horn
Mouse spinal cord dorsal horn
Sonstige Hinweise
Caterina, M.J., et al. 1999. Nature398, 436.
Gau, A., et al. 1999. Eur. J. Neurosci.11, 946.
Michael, G.J., and Priestley, J.V. 1999. J. Neurosci.19, 1844.
Caterina, M.J., et al. 1997. Nature389, 816.
Szallasi, A. 1994. Gen. Pharmacol.25, 223.
Beven, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330.
Fields, H.L. 1987. Pain (New York: McGraw-Hill).
Gau, A., et al. 1999. Eur. J. Neurosci.11, 946.
Michael, G.J., and Priestley, J.V. 1999. J. Neurosci.19, 1844.
Caterina, M.J., et al. 1997. Nature389, 816.
Szallasi, A. 1994. Gen. Pharmacol.25, 223.
Beven, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330.
Fields, H.L. 1987. Pain (New York: McGraw-Hill).
Immunohistochemistry was performed on mouse spinal cord sections fixed in 4% paraformaldehyde. Immunohistochemical staining results correlate well with other independent reports and in situ hybridization studies. Antibody should be titrated for optimal results in individual systems.
Rechtliche Hinweise
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Klaus Bielefeldt et al.
American journal of physiology. Gastrointestinal and liver physiology, 291(5), G987-G997 (2006-05-27)
Recent studies suggest that the capsaicin receptor [transient receptor potential vanilloid (TRPV)1] may play a role in visceral mechanosensation. To address the potential role of TRPV1 in vagal sensory neurons, we developed a new in vitro technique allowing us to
N J Spencer et al.
Neuroscience, 153(2), 518-534 (2008-04-09)
Rodents detect visceral pain in response to noxious levels of rectal distension. However, the mechanoreceptors that innervate the rectum and respond to noxious levels of rectal distension have not been identified. Here, we have identified the mechanoreceptors of capsaicin-sensitive rectal
M Kawashima et al.
European journal of histochemistry : EJH, 56(2), e21-e21 (2012-06-13)
Transient receptor potential vanilloid subfamily member 1 (TRPV1) is activated by capsaicin, acid, and heat and mediates pain through peripheral nerves. In the tongue, TRPV1 expression has been reported also in the epithelium. This indicates a possibility that sensation is
Nathaniel A Jeske et al.
Pain, 146(3), 301-307 (2009-09-22)
Post-translational modifications on various receptor proteins have significant effects on receptor activation. For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat. Although
Chiao-Chi Chen et al.
Scientific reports, 9(1), 12348-12348 (2019-08-28)
Gout is one of the most painful disease conditions. The central mechanism of pain processing in this condition remains elusive. Cerebral blood volume (CBV) responses are faithful correlates of brain activity changes; the application of CBV-weighted functional magnetic resonance imaging
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