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Key Documents

MABT335

Sigma-Aldrich

Anti-Desmoglein-3, clone 5G11 Antibody

clone 5G11, from mouse

Synonym(e):

Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, Cadherin family member 6

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

5G11, monoclonal

Speziesreaktivität

human

Methode(n)

immunohistochemistry: suitable (paraffin)

Isotyp

IgG1κ

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... DSG3(1830)

Allgemeine Beschreibung

Desmoglein-3 (DSG3) is a calcium binding membrane protein that is localized desmosome cellular junctions and interacts with plaque proteins and intermediate filaments at cell-cell adhesion points. Desmosomes are cell-cell junctions between epithelial, myocardial and other cells types. Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament cytoskeleton. It is thought that raft membrane microdomains play a role in desmosome homeostasis by regulating the dynamics of desmosome assembly and disassembly. In human keratinocytes, Desmoglein-3 (DSG3) is raft associated and disruption of rafts prevents desmosome assembly. Desmoglein-3 is one of four sister proteins in the desmoglein family. Desmoglein-3 is also the autoantigen for Pemphigus vulgaris (PV) a lethal skin disease that is a result of autoantibodies against Desmoglein-3.

Immunogen

Recombinant protein corresponding to human Desmoglein-3.

Anwendung

Research Category
Zellstruktur
Research Sub Category
Adhäsions-Proteine (CAMs – Zelladhäsionsmoleküle)
Immunohistochemistry Analysis: A representative lot detected Isocitrate Desmoglein-3 in human scalp hair follicles and epidermal inclusions (Wu, H., et al. (2003). J Invest Dermatology. 120(6):1152-1157).
Immunohistochemistry Analysis: A representative lot detected Isocitrate Desmoglein-3 in in human adult skin tissue (Wu, H., et al. (2013). New England Journal of Med. 343(1):31-35).
This Anti-Desmoglein-3, clone 5G11 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Desmoglein-3.

Qualität

Evaluated by Immunohistochemistry in human tonsil and human skin tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Desmoglein-3 in human tonsil and human skin tissue.

Zielbeschreibung

107 kDa calculated

Verlinkung

Replaces: MABT470

Physikalische Form

Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Hope E Burks et al.
The Journal of cell biology, 222(11) (2023-09-21)
Melanoma is an aggressive cancer typically arising from transformation of melanocytes residing in the basal layer of the epidermis, where they are in direct contact with surrounding keratinocytes. The role of keratinocytes in shaping the melanoma tumor microenvironment remains understudied.
Alejandra Valenzuela-Iglesias et al.
Molecular cancer research : MCR, 17(5), 1195-1206 (2019-01-19)
Loss of the desmosomal cell-cell adhesion molecule, Desmoglein 1 (Dsg1), has been reported as an indicator of poor prognosis in head and neck squamous cell carcinomas (HNSCC) overexpressing epidermal growth factor receptor (EGFR). It has been well established that EGFR
Marihan Hegazy et al.
Developmental cell, 57(24), 2683-2698 (2022-12-11)
Sorting transmembrane cargo is essential for tissue development and homeostasis. However, mechanisms of intracellular trafficking in stratified epidermis are poorly understood. Here, we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, desmoglein-1 (Dsg1). Dsg1

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