MABE933

Anti-Tudor-SN Antibody, clone 13.14.1

clone 13.14.1, 1 mg/mL, from mouse

• Synonym(e): Staphylococcal nuclease domain-containing protein 1, 100 kDa coactivator, EBNA2 coactivator p100, Tudor domain-containing protein 11, p100 co-activator, Tudor-SN
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 13.14.1, monoclonal
• Speziesreaktivität: human
• Konzentration: 1 mg/mL
• Methode(n): western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_055205
• UniProt-Hinterlegungsnummer: Q7KZF4
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SND1(27044)

Beschreibung

Allgemeine Beschreibung

Tudor-SN, also known as Staphylococcal nuclease domain-containing protein 1, 100 kDa coactivator or EBNA2 coactivator p100 or Tudor domain-containing protein 11 or p100 co-activator, and encoded by the gene name SND1 or TDRD11, plays an important role in PIM1 regulation of MYB acitivity and acts as a transcriptional activatior of EBNA-2. SND1 also interacts with EAV, NSP1,GTF2E1 and GTF2E2, and forms a ternary complex with STAT6 and POLR2A. SND1 ic localized to the cytoplasm and in IL-4 stimulated cells SND1 co-localizes with STAT6 in the nucleus. SND1 plays an important role in the assembly of STAT6 transcriptome and stimulates IL-4-dependent transcription by mediating interaction between STAT6 and CBP.

Immunogen

Epitope: C-terminus

Recombinant protein corresponding to the C-terminus of human Tudor-SN.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
Nuclear Receptors

This Anti-Tudor-SN Antibody, clone 13.14.1 is validated for use in Western Blotting for the detection of Tudor-SN.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Tudor-SN in 10 µg of HeLa cell lysate.
Western Blotting Analysis: A representative lot detected Tudor-SN in HeLa and Hek 293 cell lysate (Ota, H., et al. (2013). Cell. 153:575-589).

Qualität

Evaluated by Western Blotting in HEK-293 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Tudor-SN in 10 µg of HEK-293 cell lysate.

Zielbeschreibung

~110 kDa observed. The calculated molecular weight of this protein is 101 kDa, but can be observed at ~110 kDa due to post transitional modifications.

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids