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MAB396

Anti-Glutamate Receptor 2 & 4 Antibody, clone 3A11

clone 3A11, Chemicon®, from mouse

Synonym(e):

GluR2/4

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Über diesen Artikel

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
3A11, monoclonal
Application:
ELISA, ICC, IHC, IP, RIA, WB
Citations:
10
Technischer Dienst
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Unterstützung erhalten

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3A11, monoclonal

species reactivity

monkey, human, rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, radioimmunoassay: suitable, western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_000839.2

UniProt accession no.

Q14416, Q14833

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIA2(2891)
rat ... Gria2(29627)
rhesus monkey ... Gria2(574344)

Immunogen

Recombinant fusion protein TrpE-GluR2

Application

Detect Glutamate Receptor 2 & 4 using this Anti-Glutamate Receptor 2 & 4 Antibody, clone 3A11 validated for use in ELISA, IC, IH, IP, RIA & WB.
Immunohistochemistry on 4% paraformaldehyde fixed

tissue: 1:500-1,000

Immunocytochemistry

ELISA

RIA

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Biochem/physiol Actions

Glutamate Receptor 2 (GluR2) by Western blot and RIA. When using MAB396 for immunohistochemistry or immunoprecipitation it recognizes both GluR2 and GluR4.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in PBS, no preservative.

Preparation Note

Maintain at -20°C in undiluted aliquots for up 12 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklasse

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Verwandter Inhalt

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

Anti-Glutamate Receptor 2 & 4, clone 3A11 - Data Sheet

MOUSE ANTI-GLUTAMATE RECEPTOR 2 & 4 (GluR2/4)

Global Trade Item Number

SKUGTIN
MAB39604053252723223