CHGE73HS3

Millipore Express^® SHC High Area 0.5/0.2µm Cartridge 30

Code 7 Silicone, Autoclavable and SIP

• Synonym(e): Millipore Express^™ SHC High Area Cartridge
• UNSPSC Code: 23151806

Eigenschaften

• Produktname: Millipore Express^™ SHC High Area Cartridge, Chemistry: 0.5 / 0.2 µm Hydrophilic Polyethersulfone (PES) Configuration: 30 in. Code 7
• Quality Segment: 400
• material: polypropylene support, silicone seal
• reg. compliance: meets FDA 21 CFR 177-182 (all component materials)
• sterility: non-sterile
• sterilization compatibility: autoclavable compatible; steam-in-place compatible
• product line: EMPROVE^® Filter, Millipore Express^®
• feature: hydrophilic
• manufacturer/tradename: Millipore Express^®
• parameter: ≤169.2 mL/min air diffusion at 2.75 bar (40 psig) (in water), 1700 mbar max. differential pressure (25 psi) at 80 °C (Forward), 1700 mbar max. inlet pressure (25 psi) at 80 °C (Forward), 2100 mbar max. inlet pressure (30 psi) at 25 °C (Reverse), 340 mbar max. differential pressure (5 psi) at 135 °C (Forward), 340 mbar max. inlet pressure (5 psi) at 135 °C (Forward), 69 mbar max. inlet pressure (1 psi) at 135 °C (Reverse), 6900 mbar max. differential pressure (100 psi) at 25 °C (Forward), 6900 mbar max. inlet pressure (100 psi) at 25 °C (Forward)
• technique(s): sterile filtration: suitable
• L: 30 in.
• W: 2.8 in.
• cartridge nominal length: 30 in. (75 cm)
• filter diam.: 2.7 in. (6.9 cm)
• filter filtration area: 3.0 m²
• filter size: 30 in.
• impurities: ≤0.25 EU/mL bacterial endotoxins (LAL test, aqueous extraction), <0.25 EU/mL USP bacterial endotoxins (LAL test, sample aqueous extraction)
• matrix: Millipore Express^® SHC High Area
• pore size: 0.5/0.2 μm pore size
• bubble point: ≥4000 mbar (58 psig), air with water
• cartridge code: Code 7

Beschreibung

General description

Millipore Express^® SHC filters have an on-board polyethersulfone membrane prefilter which protects the 0.2 μm membrane from premature plugging and extends filtration capacity, so you get sterilizing-grade performance with superior throughput. The CHGE73HS3 cartridge filter features a 0.5/0.2 μm pore size, a filtration area of 0 and a Code 7 cartridge configuration.

Millipore Express^® SHC filters provide you with a single solution for a range of process fluids, minimizing validation efforts and simplifying filter inventory and stocking requirements. With Millipore Express^® SHC filters, you increase productivity, shorten cycle-time and reduce cost.

Application

• Media additives
• Column protection
• Concentrated protein streams
• Cell harvest (post clarification)
• Caustics/pH adjusters
• Buffers
• CIP solution

Features and Benefits

• High capacity, high flux hydrophilic PES membranes
• Validated sterilizing-grade performance
• Easy wetting and integrity testing
• Superior throughput in high fouling streams, including media and protein containing solutions
• Increased capacity for improved process efficiency and economy
• Broad chemical compatibility across a wide pH range (1-14) — caustic compatible

Packaging

Double Easy-Open bag

Preparation Note

Sterilization Method: 5 autoclave cycles of 60 min at 126 °C or 5 forward SIP cycles of 30 min at 135 °C

This product was manufactured with a MILLIPORE EXPRESS^® membrane which meets the criteria for a "non-fiber releasing" filter as defined in 21 CFR 210.3 (b) (6).

Analysis Note

After sterilization and a controlled water flush of 60 L, samples exhibited <500 ppb TOC per USP 643 and < 1.3 μS/cm per USP 645 at 25 °C.

Bacterial Retention: Samples were quantitatively retentive of a minimum Brevundimonas diminuta challenge concentration of 1 x 10⁷ CFU/cm² using ASTM^® F838 methodology.

Other Notes

Directions for Use

• Organism Retention: Microorganism
• Mode of Action: Filtration (size exclusion)
• Application: BioProcessing
• Intended Use: Reduction or removal of microorganism/bioburden
• Instructions for Use: Please refer wetting instructions of Filters with MILLIPORE EXPRESS^® Membrane user guide
• Storage Statement: Please refer Filters with MILLIPORE EXPRESS^® Membrane user guide
• Disposal Statement: Dispose of in accordance with applicable federal, state and local regulations

These products are manufactured in a facility which adheres to FDA Good Manufacturing Practices.

Legal Information

Express is a trademark of Merck KGaA, Darmstadt, Germany

ASTM is a registered trademark of American Society for Testing and Materials

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

MILLIPORE EXPRESS is a registered trademark of Merck KGaA, Darmstadt, Germany