AG216

Presenilin-2, blocking peptide for AB5056

• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.25

Eigenschaften

• Konzentration: 1.0 mg/mL
• Qualitätsniveau: 300
• Methode(n): cell based assay: suitable
• UniProt-Hinterlegungsnummer: P49810
• Angaben zum Gen: human ... PSEN2(5664)

Beschreibung

Allgemeine Beschreibung

FUNCTION: SwissProt: P49810 # Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
SIZE: 448 amino acids; 50140 Da
SUBUNIT: Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
DOMAIN: SwissProt: P49810 The PAL motif is required for normal active site conformation (By similarity).
PTM: Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. & Phosphorylated on serine residues.
DISEASE: SwissProt: P49810 # Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889, 104300]. AD is an autosomal dominant neurodegenerative disorder characterized by progressive dementia, parkinsonism, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. Early onset AD is the most severe form of the disease, with complete penetrance and an onset occurring as early as 30 years of age. The second form is late- onset AD (LOAD), with mean age of onset greater than 58 years. & Three causative genes have been identified that when mutated lead to presenile Alzheimer
DISEASE: APP (amyloid precursor protein gene), PSEN1 and PSEN2. These three genes account for half of the families with autosomal dominant presenile AD, which represent approximately 10% of the whole AD population. In addition, apolipoprotein E has been identified as a risk- modifying locus.
SIMILARITY: Belongs to the peptidase A22A family.

Anwendung

For use in blocking the reactivity of AB5056.

Optimal working dilution must be determined by the end user.

Physikalische Form

Liquid in sterile water. Contains no preservative.

Lagerung und Haltbarkeit

Maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids