8.52412

Fmoc-His(MBom)-OH

N-α-Fmoc-3-methoxybenzyloxymethyl-L-histidine Novabiochem^®

• Synonym(e): N-α-Fmoc-N-π-(p-methoxybenzyloxymethyl)-L-histidine
• Empirische Formel (Hill-System): C₃₀H₂₉N₃O₆
• Molekulargewicht: 527.57
• UNSPSC-Code: 12352209

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: Fmoc
• Lagertemp.: 15-25°C

Beschreibung

Allgemeine Beschreibung

A novel histidine derivative for Fmoc SPPS in which the π-imidazole nitrogen is blocked with the acid-labile MBom group, In contrast to Fmoc-His(Trt)-OH, coupling of this derivative is free from the risk of racemization, even under base-mediated coupling conditions. Methoxyamine should be added to the cleavage mixture to scavenge liberated formaldehyde.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] H. Hibino et al. (2011) Tetrahedron lett., 52, 4947.

Hinweis zur Analyse

Colour (visual): white to off white
Appearance of substance (visual): powder
Purity (HPLC): ≥ 98.0 % (a/a)
Purity (DC(BAWO)): ≥ 98 %
Identity (IR): passes test
Solubility (1 mmole in 2 ml DMF): clear soluble
Enantiomeric purity: ≥ 99.5 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable