8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

• Synonym(e): N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
• Empirische Formel (Hill-System): C₈H₁₇N₃ · xHCl
• CAS-Nummer: 25952-53-8
• Molekulargewicht: 155.24 (free base basis)
• MDL-Nummer: MFCD00012503
• UNSPSC-Code: 12352107
• EG-Index-Nummer: 247-361-2
• NACRES: NA.22

Eigenschaften

• product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
• Qualitätsniveau: 200
• Form: solid
• Eignung der Reaktion: reaction type: Coupling Reactions
• mp (Schmelzpunkt): 110-115 °C
• Anwendung(en): peptide synthesis
• Lagertemp.: −20°C (−15°C to −25°C)
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• InChIKey: FDXPUDRRFDHONO-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Anwendung

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:

• A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
• A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
• A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H302 - H311 - H315 - H317 - H373 - H410
• P-Sätze: P260 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P314
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Lagerklassenschlüssel: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable