658452

AG 126

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

• Synonym(e): AG 126, α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
• Empirische Formel (Hill-System): C₁₀H₅N₃O₃
• CAS-Nummer: 118409-62-4
• Molekulargewicht: 215.17
• MDL number: MFCD00236448
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: 5 mg/mL, DMF: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [N+](=O)([O-])c1c(cc(cc1)C=C(C#N)C#N)O
• InChI: 1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
• InChI key: DUQADSPERJRQBW-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42^MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC₅₀ = 15.38 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-2 activity

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells

Other Notes

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.

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Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3