559406

SB 328437

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

• Synonym(e): SB 328437, (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
• Empirische Formel (Hill-System): C₂₁H₁₈N₂O₅
• CAS-Nummer: 247580-43-4
• Molekulargewicht: 378.38
• MDL-Nummer: MFCD16618397
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 100 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• InChIKey: VMFGCGRAIBLAFY-IBGZPJMESA-N

Beschreibung

Allgemeine Beschreibung

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of ¹²⁵I-eotaxin and ¹²⁵I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC₅₀ = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC₅₀ = 38, 35, and 20 nM, respectively).

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4 with IC₅₀ values of 38, 35, and 20 nM, respectively. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis (IC₅₀ values: 32, 25, and 55 nM, respectively).

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
CC chemokine receptor-3 (CCR3)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

White, J.R., et al. 2000. J. Biol. Chem.275, 36626.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable