539610

PKC_ζ/ι Pseudosubstrate Inhibitor

The PKC_ζ/ι Pseudosubstrate Inhibitor controls the biological activity of PKC_ζ/ι. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): PKC_ζ/ι Pseudosubstrate Inhibitor, SIYRRGARRWRKL, Protein Kinase C _ζ/ι Pseudosubstrate Inhibitor, SIYRRGARRWRKL, Protein Kinase C_ζ/ι Pseudosubstrate Inhibitor
• Empirische Formel (Hill-System): C₇₆H₁₂₈N₃₀O₁₆
• Molekulargewicht: 1718.02
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: lyophilized
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Löslichkeit: glacial acetic acid: 2 mg/mL; water: 2 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A selective, reversible, and substrate competitive inhibitor of protein kinase C_ζ and protein kinase C_ι (PKC_ζ/ι) isozymes.

Non-cell-permeable protein kinase C_ζ and protein kinase C_ι pseudosubstrate sequence peptide that can be used as a selective, reversible, and substrate competitive inhibitor PKC_ζ/ι in in vitro kinase assays.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
PKCζ

Product does not compete with ATP.

Reversible: yes

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

H-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH

Physikalische Form

Supplied as a trifluoroacetate salt.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Sajan, M.P., et al. 1999. J. Biol. Chem.274, 30495.
Laudanna, C., et al. 1998. J. Biol. Chem.273, 30306.
Standaert, M.L., et al. 1997. J. Biol. Chem.272, 30075.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable