5.34360

Autophagy Inhibitor VII

• Synonym(e): Autophagy Inhibitor VII, 6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
• Empirische Formel (Hill-System): C₂₀H₂₆ClN₃
• Molekulargewicht: 343.89
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic); protect from light
• Farbe: white to pale yellow
• Löslichkeit: DMSO: 1.6 mg/mL; water: 50 mg/mL
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD₅₀ = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD₅₀ = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem./physiol. Wirkung

Cell permeable: yes

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Physikalische Form

Supplied as HCl salt.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Wang, T., et al. 2015. J. Med. Chem.58, 3025.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable