362331
GAG Agonist, Adhesamine - Calbiochem
Synonym(e):
Glycosaminoglycans Agonist
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About This Item
Assay
≥80% (HPLC)
Form
solid
Farbe
light yellow
Löslichkeit
DMSO: 25 mg/mL
Allgemeine Beschreibung
A symmetrical nonpeptidyl cationic diaryldispirotripiperazine compound that binds GAGs (glycosaminoglycans) in a reversible manner (KD = 0.39, 4.67, and 5.85 μM for heparin, heparan sulfate, and keratin sulfate, respectively) and effectively promotes adhesion (by ~100 and 600% at 60 μM, respectively) and growth (by ~80 and 50% in 72 h at 1 μM, respectively) of HepG2 and Jurkat cells in a dose-dependent manner. Binding studies using heparin-derived oligosaccharides indicate that the major mode of interaction involves the binding of a hexasaccharide unit by two adhesamine molecules (KD = 0.12 μM). Primary murine hippocampal neurons cultured in the presence of adhesamine are reported to exhibit earlier differentiation as well as improved survival rate when compared with neurons cultured on poly-L-lysine-coated surface. A GAGs binding antagonist Surfen is also available under Cat. No. 362330.
The GAG Agonist, Adhesamine controls the biological activity of GAG. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
Rekonstituierung
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Lagerklassenschlüssel
10-13 - German Storage Class 10 to 13
Analysenzertifikate (COA)
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Mitsunobu Hoshino et al.
The Biochemical journal, 427(2), 297-304 (2010-02-12)
Attachment to the substrate is essential for both survival and differentiation of various kinds of cells, such as neurons and epithelial cells. We recently found a small synthetic molecule, adhesamine, which boosts adhesion and growth of mammalian cells. In the
Sayumi Yamazoe et al.
Chemistry & biology, 16(7), 773-782 (2009-07-29)
During an image-based phenotype screening of our chemical library, we noted a small molecule that boosts the adhesion and growth of human cells. Chemical and cell biological experiments suggest that the diaryldispirotripiperazine derivative (adhesamine) targets selective cell-surface glycosaminoglycans, especially heparan
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