361558
GSK-3 Inhibitor XV - Calbiochem
The GSK-3 Inhibitor XV controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(e):
GSK-3 Inhibitor XV - Calbiochem
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C25H14BrN3O6Ru
Molekulargewicht:
633.37
UNSPSC-Code:
12352200
Qualitätsniveau
Assay
≥98% (HPLC)
Form
solid
Hersteller/Markenname
Calbiochem®
Lagerbedingungen
OK to freeze
protect from light
Farbe
purple
Löslichkeit
DMSO: 6 mg/mL
Versandbedingung
wet ice
Lagertemp.
−20°C
Allgemeine Beschreibung
The racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
Biochem./physiol. Wirkung
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively
Verpackung
Packaged under inert gas
Warnhinweis
Toxicity: Standard Handling (A)
Rekonstituierung
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Sonstige Hinweise
Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem7, 1443.
Rechtliche Hinweise
Sold for research purposes only, pursuant to an agreement with University of Pennsylvania.Sold under license of U.S. Patent 7,488,817.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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