344597

FTY720

• Synonym(e): 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl, FTY720
• Lineare Formel: C19H33NO2.HCl
• CAS-Nummer: 162359-56-0
• NACRES: NA.51
• UNSPSC Code: 12352200
• Form: solid
• Storage condition: OK to freeze

Eigenschaften

• form: solid
• storage condition: OK to freeze
• solubility: soluble (DMSO (20 mg/ml) or Ethanol (20 mg/ml))
• storage temp.: −20°C

Beschreibung

General description

A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).