236020

Etomoxir

≥98% (HPLC), solid, CPT-1 inhibitor

• Synonym(e): Etomoxir, R(+)-2-[6-(4-Chlorophenoxy)hexyl]-Oxiran-2-Carboxylsäure-Natriumsalzhydrat
• Empirische Formel (Hill-System): C₁₅H₁₈ClO₄ · Na
• CAS-Nummer: 828934-41-4
• Molekulargewicht: 320.74
• MDL number: MFCD07787411
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Produktname: Etomoxir, A cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 50 mg/mL (or water)
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: [Na+].Clc1ccc(cc1)OCCCCCC[C@]2(OC2)C(=O)[O-]
• InChI: 1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1
• InChI key: RPACBEVZENYWOL-XFULWGLBSA-M

Beschreibung

General description

Etomoxir (ETO), an irreversible inhibitor of carnitine palmitoyltransferase I (CPT1), primarily impacts fatty acid oxidation. It is an epoxide-based medium-chain fatty acid used to study the biological effects of mitochondrial fatty acid β-oxidation. ETO shifts energy metabolism from fatty acids to glucose oxidation. Its mechanism of action involves reducing the transport of non-esterified fatty acids (NEFA) into the mitochondrial matrix, which subsequently reduces the substrate available for β-oxidation.

Application

Etomoxir has been used in:

• the evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument[1]
• cell stimulation experiments to study its effects on fatty acid oxidation in metabolic syndrome-associated synoviocytes[2]
• Seahorse assays to assess fatty acid oxidation in cultured cells by inhibiting carnitine palmitoyltransferase I (CPT1)[3]

Other Notes

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Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxizität: Toxisch (F)

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable