230950

Ciglitazone

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

• Synonym(e): Ciglitazone, (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I
• Empirische Formel (Hill-System): C₁₈H₂₃NO₃S
• CAS-Nummer: 74772-77-3
• Molekulargewicht: 333.45
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00865499
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Eigenschaften

• Quality Segment: 100
• description: RTECS - XJ5813700
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: tan
• solubility: DMSO: ≥25 mg/mL, ethanol: ≥25 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
• InChI key: YZFWTZACSRHJQD-UHFFFAOYSA-N

Beschreibung

General description

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 3 µM).

Biochem/physiol Actions

Cell permeable: no

EC50 = 3 µM as PPARγ agonist

Primary Target
Selective PPARγ agonist

Product does not compete with ATP.

Reversible: no

Preparation Note

Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable