208922-M

CaMKII Inhibitor, CK59

The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): CaMKII Inhibitor, CK59, 2-(2-Hydroxyethylamino)-6-aminohexylcarbamic acid tert-butyl ester-9-isopropylpurine, CK59
• Empirische Formel (Hill-System): C₂₁H₃₇N₇O₃
• CAS-Nummer: 140651-18-9
• Molekulargewicht: 435.56
• MDL number: MFCD09262258
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: semisolid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: semisolid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: 10 mg/mL
• storage temp.: 2-8°C
• SMILES string: [nH]1nc(c(c1N)N=Nc2ccc(cc2)O)N
• InChI: 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
• InChI key: AYZRKFOEZQBUEA-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC₅₀<10 µM) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 µM) and GLUT4 membrane translocation (IC₅₀ = 100 µM) in 3T3-L1 adipocytes.

A cell-permeable Olomoucine analog that acts as a CaMKII inhibitor (IC₅₀<10 M) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 M) and GLUT4 membrane translocation (IC₅₀ = 100 M) in 3T3-L1 adipocytes.

Preparation Note

Following reconstitution aliquot, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Konstantopoulos, N., et al. 2007. Endocrinology, 148, 374.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable