09-466

Anti-phospho-CrkL (Tyr207) Antibody

Upstate^®, from rabbit

• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: mouse, rat, human
• Hersteller/Markenname: Upstate^®
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_005198
• UniProt-Hinterlegungsnummer: P46109
• Versandbedingung: dry ice
• Posttranslationale Modifikation Target: phosphorylation (pTyr207)
• Angaben zum Gen: human ... CRKL(1399)

Beschreibung

Allgemeine Beschreibung

CRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition.

Spezifität

Recognizes CrkL only when phosphorylated on Tyr207.

Immunogen

KLH synthetic peptide including and encompassing Tyr 207 of human CrkL.

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
Cytoskelettale Signalübertragung

Detect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.

Qualität

Routinely evaluated by western blot on K563 cell lysates.

Zielbeschreibung

39 kDa

Physikalische Form

Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Hinweis zur Analyse

Control
K562

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2