07-449-AF647

Anti-trimethyl Histone H3 (Lys27), Alexa Fluor^™ 647 Conjugate Antibody

0.5 mg/mL, from rabbit

• Synonym(e): Histone H3.1t, H3/t, H3t, H3/g
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: ALEXA FLUOR^™ 647
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): mouse (based on 100% sequence homology)
• Konzentration: 0.5 mg/mL
• Methode(n): immunocytochemistry: suitable
• NCBI-Hinterlegungsnummer: NM_003493
• UniProt-Hinterlegungsnummer: Q16695
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: trimethylation (Lys27)
• Angaben zum Gen: human ... H3C1(8350) ; mouse ... H3C1(360198)

Beschreibung

Allgemeine Beschreibung

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-449.

Immunogen

Linear peptide corresponding to Histone H3 trimethylated at Lys27.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
Histone

This Anti-trimethyl Histone H3 (Lys27) antibody is validated for use in ICC for the detection of trimethyl Histone H3 (Lys27).

Qualität

Evaluated by Immunocytochemistry Analysis: in HeLa cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected trimethyl Histone H3 (Lys27) in HeLa cells.

Alexa Fluor^™ is a registered trademark of Life Technologies.

Zielbeschreibung

~17 kDa observed (Refer to Cat. No. 07-449)

Physikalische Form

Protein A purified

Purified rabbit conjugate antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable