462888
2,4-Dimethylphenylhydrazin -hydrochlorid
97%
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Alle Fotos(1)
About This Item
Qualitätsniveau
Assay
97%
Form
solid
mp (Schmelzpunkt)
184 °C (dec.) (lit.)
SMILES String
Cl.Cc1ccc(NN)c(C)c1
InChI
1S/C8H12N2.ClH/c1-6-3-4-8(10-9)7(2)5-6;/h3-5,10H,9H2,1-2H3;1H
InChIKey
ZLGXGLXFBMIVPU-UHFFFAOYSA-N
Allgemeine Beschreibung
2,4-Dimethylphenylhydrazine hydrochloride is a hydrazine derivative.
Anwendung
2,4-Dimethylphenylhydrazine hydrochloride was used for the synthesis of J147 (a novel neurotrophic drug) and its precursor desmethyl-J147. It was also used in the synthesis of 1-(2,4-dimethylphenyl)-4-methyl-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid, ethyl ester.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Bioorganic & medicinal chemistry letters, 23(2), 524-527 (2012-12-15)
J147 was synthesized from 2,4-dimethylphenylhydrazine hydrochloride and 3-methoxybenzaldehyde in 2 steps with 71% overall yield. The precursor desmethyl-J147 was synthesized from 3-hydroxybenzaldehyde and 2,4-dimethylphenylhydrazine hydrochloride in 4 steps with 63% overall yield. [(11)C]J147 was prepared from desmethyl-J147 with [(11)C]CH(3)OTf through
Bioorganic & medicinal chemistry, 14(11), 3712-3720 (2006-02-10)
Cannabinoid type-1 (CB(1)) receptor ligands, derived from the 1,5-diarylpyrazole core template of rimonabant (Acomplia), have been the focus of several studies aimed at examining structure-activity relationships (SARs). The purpose of this study was to design and synthesize a set of
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