407135

N,N-Dibutyl-L-(+)-norephedrin

97%

• Synonym(e): (+)-DBNE, (1R,2S)-(+)-2-(Dibutylamino)-1-phenyl-1-propanol
• Lineare Formel: [CH₃(CH₂)₃]₂NCH(CH₃)CH(C₆H₅)OH
• CAS-Nummer: 115651-77-9
• Molekulargewicht: 263.42
• MDL-Nummer: MFCD00142689
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24865427

Eigenschaften

• Assay: 97%
• Optische Aktivität: [α]20/D +21°, c = 2 in chloroform
• Brechungsindex: n20/D 1.501 (lit.)
• bp: 121 °C/0.1 mmHg (lit.)
• Dichte: 0.94 g/mL at 25 °C (lit.)
• SMILES String: CCCCN(CCCC)[C@@H](C)[C@H](O)c1ccccc1
• InChI: 1S/C17H29NO/c1-4-6-13-18(14-7-5-2)15(3)17(19)16-11-9-8-10-12-16/h8-12,15,17,19H,4-7,13-14H2,1-3H3/t15-,17-/m0/s1
• InChIKey: BRRGNOFUBFINSX-RDJZCZTQSA-N

Beschreibung

Allgemeine Beschreibung

(1R,2S)-(+)-2-(Dibutylamino)-1-phenyl-1-propanol, a norephedrine derivative, is a chiral auxiliary for asymmetric synthesis.

Anwendung

(+)-DBNE reacts with nickel bromide (NiBr₂) to form a chiral catalyst, which can catalyze the enantioselective conjugate addition of dialkylzincs to α,β-unsaturated ketones leading to the formation of optically active β-substituted ketones.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 230.0 °F - closed cup
• Flammpunkt (°C): 110 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type ABEK (EN14387) respirator filter