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Sigma-Aldrich

4-Chlor-3-ethylphenol

97%

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About This Item

Lineare Formel:
ClC6H3(C2H5)OH
CAS-Nummer:
14143-32-9
Molekulargewicht:
156.61
EG-Nummer:
237-991-6
MDL-Nummer:
MFCD00010822
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24856895
NACRES:
NA.22

Assay

97%

Form

solid

mp (Schmelzpunkt)

45-50 °C (lit.)

SMILES String

CCc1cc(O)ccc1Cl

InChI

1S/C8H9ClO/c1-2-6-5-7(10)3-4-8(6)9/h3-5,10H,2H2,1H3

InChIKey

DVKVZPIRWWREJC-UHFFFAOYSA-N

Anwendung

4-Chloro-3-ethylphenol is a ryanodine receptor antagonist and is commonly used as research tool and diagnostic reagent for malignant hyperthermia.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

235.4 °F - closed cup

Flammpunkt (°C)

113 °C - closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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L J Janssen et al.
The American journal of physiology, 276(5 Pt 1), L744-L753 (1999-05-18)
We examined cytosolic concentration of Ca2+ ([Ca2+]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca2+]i), membrane currents (subsarcolemmal [Ca2+]i), and contractions (deep cytosolic [Ca2+]i). Acetylcholine (10(-4) M) elicited fluorimetric, electrophysiological, and mechanical responses. Caffeine (5
Aniko Varadi et al.
Diabetes, 51 Suppl 1, S190-S201 (2002-01-30)
The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca(2+) from the ER
Francisco H Andrade et al.
Investigative ophthalmology & visual science, 46(12), 4541-4547 (2005-11-24)
The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca2+ concentration ([Ca2+]i). Mitochondrial Ca2+ influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca2+ uptake regulates [Ca2+]i and production of
Bo Zeng et al.
British journal of pharmacology, 171(5), 1250-1259 (2014-03-29)
Depletion of the Ca(2+) store by ryanodine receptor (RyR) agonists induces store-operated Ca(2+) entry (SOCE). 4-Chloro-3-ethylphenol (4-CEP) and 4-chloro-m-cresol (4-CmC) are RyR agonists commonly used as research tools and diagnostic reagents for malignant hyperthermia. Here, we investigated the effects of
M U Gerbershagen et al.
European journal of anaesthesiology, 19(2), 135-140 (2002-05-10)
The in vitro contracture test with halothane and caffeine is the current gold standard for diagnosis of malignant hyperthermia. This test has a sensitivity of 99.0% but a specificity of only 93.6%. Therefore, an alternative drug is desirable which distinguishes
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