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Merck

SCN11A

sodium channel, voltage-gated, type XI, alpha subunit

Synonyme:
NAV1.9, NaN, SCN12A, SNS-2
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(11280) Summary: Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]
  • Mouse(24046) sodium channel, voltage-gated, type XI, alpha
  • Rat(29701) sodium channel, voltage-gated, type XI, alpha subunit
  • domestic guinea pig(100734219) sodium channel, voltage-gated, type XI, alpha subunit
  • Domestic Rabbit(100349709) sodium channel, voltage-gated, type XI, alpha subunit
  • sheep(101117022) sodium channel, voltage-gated, type XI, alpha subunit
  • cow(535956) sodium channel, voltage-gated, type XI, alpha subunit
  • domestic cat(101085312) sodium channel, voltage-gated, type XI, alpha subunit
  • dog(485593) sodium channel, voltage-gated, type XI, alpha subunit
  • naked mole-rat(101723747) sodium channel, voltage-gated, type XI, alpha subunit

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-SCN11A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-SCN11A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Monoclonal Anti-SCN11A, (C-terminal) antibody produced in mouse, clone 2B10, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
western blot
Anti-Sodium Channel NaV1.9 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Speziesreaktivität
rat
Anwendung
western blot
Monoklonaler Anti-Natriumkanal, Pan in Maus hergestellte Antikörper, ~1 mg/mL, clone K58/35, purified immunoglobulin,
Speziesreaktivität
mammals
Anwendung
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
Lidocain -hydrochlorid Monohydrat, solid,
Spezies
human
Lidocain -hydrochlorid, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Procain -hydrochlorid, ≥97%,
Spezies
human
Lidocain, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Lidocainhydrochlorid, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human

Small Molecule - Ligand

Produktnummer
Beschreibung
Spezies
Lamotrigin, ≥98%, powder,
Spezies
rat, human
Carbamazepin, powder,
Spezies
rat, human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human SCN11A,
Spezies
human