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BRCA2

breast cancer 2, early onset

Synonyme:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
Spezies:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...Mehr
UniProtKB-ID:
P51587, O00183, O15008, Q13879, Q5TBJ7
Gen-ID:
  • Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
  • Mouse(12190) breast cancer 2
  • Rat(360254) breast cancer 2, early onset
  • domestic guinea pig(100713136) breast cancer 2, early onset
  • Zebrafish(566758) breast cancer 2, early onset
  • naked mole-rat(101698015) breast cancer 2, early onset
  • chicken(374139) breast cancer 2, early onset
  • sheep(101109980) breast cancer 2, early onset
  • fruit fly(37916) Breast cancer 2, early onset homolog
  • cow(507069) breast cancer 2, early onset
  • dog(474180) breast cancer 2, early onset
  • domestic cat(493878) breast cancer 2, early onset
  • Horse(100064578) breast cancer 2, early onset

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
OP95
Anti-BRCA2 (Ab-1) Mouse mAb (2B), liquid, clone 2B, Calbiochem®,
Speziesreaktivität
human
Anwendung
HPA026815
Anti-BRCA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
ZRB2563
Anti-BRCA2 Antibody, clone 1H2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human
Anwendung
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
SAB4502860
Anti-BRCA2 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, rat
Anwendung
ELISA
immunohistochemistry
WH0000675M1
Monoclonal Anti-BRCA2 antibody produced in mouse, clone 3D12, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
western blot

esiRNA

Produktnummer
Beschreibung
Spezies
EHU031451
MISSION® esiRNA, targeting human BRCA2,
Spezies
human
EMU075501
MISSION® esiRNA, targeting mouse Brca2,
Spezies
mouse