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SML2659

Sigma-Aldrich

Spastazoline

≥98% (HPLC)

Synonym(s):

(R)-N-(5-(tert-butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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About This Item

Empirical Formula (Hill Notation):
C20H30N8
CAS Number:
Molecular Weight:
382.51
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Spastazoline is a cell penetrant, potent and selective ATP-competitive inhibitor of spastin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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Rudolf Pisa et al.
Journal of the American Chemical Society, 141(14), 5602-5606 (2019-03-16)
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structural data for inhibitor-protein complexes
Tommaso Cupido et al.
Nature chemical biology, 15(5), 444-452 (2019-02-20)
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellular processes. To design a chemical inhibitor of

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