P5052

5α-Pregnan-3α-ol-11,20-dione

powder, ≥98% (TLC)

• Synonym(s): 3-Hydroxy-5α-pregnane-11,20-dione, Alfaxalone
• CAS Number: 23930-19-0
• NACRES: NA.77
• PubChem Substance ID: 24278637
• UNSPSC Code: 12352200
• MDL number: MFCD00083468
• Assay: ≥98% (TLC)
• Form: powder

Properties

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• drug control: USDEA Schedule IV
• color: white
• solubility: chloroform: ≥5 mg/mL, clear, colorless
• SMILES string: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
• InChI key: DUHUCHOQIDJXAT-OLVMNOGESA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRG2(2566)

Description

Biochem/physiol Actions

Neurosteroid; positive allosteric modulator of the GABA_A receptor; anesthetic.

Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABA_A receptor; anesthetic. The alpha subunit subtype of GABA_A determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves