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MTP Activity Assay Kit

Name: MTP Activity Assay Kit
Brand: SIGMA

Supplied by Roar Biomedical, Inc.

Synonym(s):

MTTP Activity Assay Kit, Microsomal triglyceride transfer protein activity assay kit

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About This Item

NACRES:

NA.84

UNSPSC Code:

12161503

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Properties

usage

sufficient for 100 fluorometric tests

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

cardiovascular diseases

storage temp.

2-8°C

Gene Information

human ... MTTP(4547)

Description

General description

Microsomal triglyceride transfer protein (MTP), a membrane-bound protein present in the liver, plays an important role in the assembly and secretion of very low density lipoprotein (VLDL). MTP is also necessary for assembly and secretion of chylomicrons by the intestine. This protein facilitates the transfer of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between phospholipid surfaces. Mutation in the MTP gene leads to abetalipoproteinemia.

Application

Suitable for measuring microsomal [triglyceride] transfer protein (MTP) activity in cell lysates or tissue homogenates, or for screening MTP activity inhibitors.

MTP Activity Assay Kit has been used to measure the activity of microsomal triglyceride transfer protein (MTP).

Biochem/physiol Actions

The MTP Activity Assay Kit is a sensitive, homogeneous fluorometric assay useful for continuous measurement of MTP activity in cell lysate or tissue homogenate. This kit includes proprietary substrates that enable the detection of MTP-mediated transfer of neutral lipid. The transfer activity results in an increase in fluorescence intensity (λ_Ex=465 nm/λ_Em=535 nm).

Features and Benefits

Compatible with high-throughput handling systems.

Analysis Note

Learn more about Roar Assay Kits for Studies in Lipoprotein Metabolism.

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This Item	MAK108	MAK106	MAK137
Sigma-Aldrich MAK110 MTP Activity Assay Kit	Sigma-Aldrich MAK108 PLTP Activity Assay Kit	Sigma-Aldrich MAK106 CETP Activity Assay Kit	Sigma-Aldrich MAK137 Phospholipase D Activity Assay Kit
description Supplied by Roar Biomedical, Inc.	description Supplied by Roar Biomedical, Inc.	description Supplied by Roar Biomedical, Inc.	description sufficient for 100 colorimetric or fluorometric tests
Gene Information human ... MTTP(4547)	Gene Information human ... PLTP(5360)	Gene Information human ... CETP(1071)	Gene Information human ... PLD1(5337), PLD2(5338), PLD3(23646), PLD4(122618), PLD5(200150), PLD6(201164) mouse ... PLD1(18805), PLD2(18806), PLD3(18807), PLD4(104759), PLD5(319455), PLD6(194908) rat ... PLD1(25096), PLD2(25097), PLD3(361527), PLD4(362792), PLD5(289270), PLD6(287366)
usage sufficient for 100 fluorometric tests	usage sufficient for 100 fluorometric tests	usage sufficient for 100 fluorometric tests	usage sufficient for 100 colorimetric or fluorometric tests
detection method fluorometric	detection method fluorometric	detection method fluorometric	detection method colorimetric, fluorometric
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
application(s) pharmaceutical	application(s) pharmaceutical	application(s) pharmaceutical	application(s) -
relevant disease(s) cardiovascular diseases	relevant disease(s) cardiovascular diseases	relevant disease(s) cardiovascular diseases	relevant disease(s) cancer

Storage Class

10 - Combustible liquids

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