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F5135

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala

collagenase substrate, chromogenic

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala
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Synonym(s):

FALGPA, N-[3-(2-Furyl)acryloyl]-L-leucyl-glycyl-L-prolyl-L-alanine

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About This Item

Empirical Formula (Hill Notation):
C23H32N4O7
CAS Number:
78832-65-2
Molecular Weight:
476.52
UNSPSC Code:
12352202
PubChem Substance ID:
329799652
NACRES:
NA.32
MDL number:
MFCD00133552
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Product Name

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala,

Quality Segment

200

UniProt accession no.

Q02111

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)\C=C\c1ccco1)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(O)=O

InChI

1S/C23H32N4O7/c1-14(2)12-17(26-19(28)9-8-16-6-5-11-34-16)21(30)24-13-20(29)27-10-4-7-18(27)22(31)25-15(3)23(32)33/h5-6,8-9,11,14-15,17-18H,4,7,10,12-13H2,1-3H3,(H,24,30)(H,25,31)(H,26,28)(H,32,33)/b9-8+/t15-,17-,18-/m0/s1

InChI key

ZLFQNOJSYZSINX-PVJKAEHXSA-N

Gene Information

mouse ... Prkcq(18761)

General description

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala or FALGPA is a synthetic substance which resemble the primary structure of collagen, and is hydrolyzed by all known collagenases.[1]
Substrate for collagenase.

Application

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala has been used for use in FALGPA assay performed using GBS (Group B Streptococci) USF704.[2]

Biochem/physiol Actions

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala or FALGPA is hydrolyzed by collagenases and the optimum pH for hydrolysis is 7.4.[1]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
G5779F7131S7388
N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala

Sigma-Aldrich

F5135

N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala

Gly-Pro-Arg-Pro amide ≥97% (HPLC)

Sigma-Aldrich

G5779

Gly-Pro-Arg-Pro amide

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

Sigma-Aldrich

F7131

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide

Sigma-Aldrich

S7388

N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

Q02111

UniProt accession no.

P02751, P04937, P11276

UniProt accession no.

-

UniProt accession no.

-

Gene Information

mouse ... Prkcq(18761)

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Gene Information

human ... ACE(1636), ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421), ACE2(70008), ACE3(498012)

Gene Information

human ... FKBP10(60681)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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