D9533 is soluble in H2O up to a concentration of 50mg/ml.
The solubility in DMSO is not assayed.
D9533
Deferoxamine mesylate salt
≥92.5% (TLC), powder, iron-chelating agent
Synonym(s):
DFX mesylate, DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt
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About This Item
Empirical Formula (Hill Notation):
C25H48N6O8 · CH4O3S
CAS Number:
Molecular Weight:
656.79
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.32
Pricing and availability is not currently available.
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Product Name
Deferoxamine mesylate salt, powder, ≥92.5% (TLC)
Quality Level
Assay
≥92.5% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
InChI
1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key
IDDIJAWJANBQLJ-UHFFFAOYSA-N
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Application
Biochem/physiol Actions
An iron chelator used often in the studies of cell proliferation and apoptosis. Also reported to induce p53.
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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How do you reconstitute them in DMSO for drug assays?
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What are the recommended storage conditions for stock solutions of item D9533, Deferoxamine mesylate salt? Additionally, is this product sensitive to light?
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Stock solutions of item D9533, Deferoxamine mesylate salt, should be aliquoted and stored at -20°C for up to 1 month. This product is not sensitive to light.
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