540110

(2R)-(−)-Glycidyl tosylate

98%

• Synonym(s): (R)-(−)-Glycidyl p-toluenesulfonate, (R)-(−)-Glycidyl tosylate, (R)-(−)-Oxirane-2-methanol p-toluenesulfonate salt
• Empirical Formula (Hill Notation): C₁₀H₁₂O₄S
• CAS Number: 113826-06-5
• Molecular Weight: 228.26
• Beilstein: 3592142
• MDL number: MFCD00010834
• UNSPSC Code: 12352005
• PubChem Substance ID: 24878442
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 98%
• mp: 46-49 °C (lit.)
• functional group: ether; tosylate
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(cc1)S(=O)(=O)OC[C@H]2CO2
• InChI: 1S/C10H12O4S/c1-8-2-4-10(5-3-8)15(11,12)14-7-9-6-13-9/h2-5,9H,6-7H2,1H3/t9-/m1/s1
• InChI key: NOQXXYIGRPAZJC-SECBINFHSA-N

Description

Application

(2R)-(-)-Glycidyl tosylate may be used to prepare:

• 1-O-hexadecyl-sn-glycerol 3-O-p-toluenesulfonate by reacting with 1-hexadecanol in the presence of boron trifluoride etherate.
• 4-Oxiranylmethoxy-(1H)-indole by reacting with 4-hydroxyindole in the presence of sodium hydride.
• [¹⁸F]Epifluorohydin, an intermediate for preparing of [¹⁸F]fluoromisonidazole.

It can also be used as a starting material in the synthesis of 1,2-diacyl-sn-3-glycerophosphocholines.

Legal Information

Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.

Safety Information

• Pictograms: GHS08,GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H317,H318,H341,H350,H411
• Precautionary Statements: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Chronic 2 - Carc. 1B - Eye Dam. 1 - Muta. 2 - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): >230.0 °F
• Flash Point(C): > 110 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves