[Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].

[Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].

Biomeditsinskaia khimiia (2013-05-09)

V O Tkachev, M V Zaĭkovskaia, A V Troitskiĭ, N G Luzgina, V A Shkurupiĭ

RESUMEN

The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.

MATERIALES

Referencia del producto

Marca

Descripción del producto

31392

Sigma-Aldrich

Dextrano from Leuconostoc spp., M_r 450,000-650,000

31390

Sigma-Aldrich

Dextrano from Leuconostoc spp., M_r ~70,000

31389

Sigma-Aldrich

Dextrano from Leuconostoc spp., M_r ~40,000

D9260

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 9,000-11,000

D5376

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000

D8821

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 60,000-76,000

D1662

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 35,000-45,000

31388

Sigma-Aldrich

Dextrano from Leuconostoc spp., M_r ~6,000

00271

Supelco

Dextran, analytical standard, for GPC, 25,000

D4876

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 150,000

09184

Sigma-Aldrich

Dextrano from Leuconostoc spp., M_r ~100,000

00269

Supelco

Dextran, analytical standard, for GPC, 5,000

I3377

Supelco

Isoniazid, analytical standard, ≥99% (TLC)

00268

Supelco

Dextran, analytical standard, for GPC, 1,000

31387

Sigma-Aldrich

Dextrano from Leuconostoc spp., M_r 15,000-25,000

31398

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, M_r ~200,000

31397

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, M_r ~60,000

31394

Sigma-Aldrich

Dextran, enzymatic synth.

D8802

Sigma-Aldrich

Dextran solution from Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)

31425

Supelco

Dextrano from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000

00894

Supelco

Dextran, analytical standard, for GPC, 270,000

D3759

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 48,000-90,000

31417

Supelco

Dextrano from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 5,000

D4626

Sigma-Aldrich

Dextrano from Leuconostoc mesenteroides, average mol wt 15,000-30,000

31416

Supelco

Dextrano from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000

31419

Supelco

Dextrano from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000

31430

Supelco

Dextran, analytical standard, for GPC, Set M_p 1,000-400,000

00891

Supelco

Dextran, analytical standard, for GPC, 50,000

00895

Supelco

Dextran, analytical standard, for GPC, 410,000

00892

Supelco

Dextran, analytical standard, for GPC, 80,000