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59356-U

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Discovery® Cyano (5 µm) HPLC Columns

Discovery® Cyano HPLC Column

L × I.D. 15 cm × 4.6 mm, HPLC Column

Sinónimos:

Columna de fase ciano ligada

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About This Item

Código UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Columna para HPLC Discovery® Cyano, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Materiales

stainless steel column

Nivel de calidad

100

Agency

suitable for USP L10

Línea del producto

Discovery®

Características

endcapped

fabricante / nombre comercial

Discovery®

envase

1 ea of

Extensión del etiquetado

4.5% Carbon loading

Parámetros

≤70 °C temp. range
400 bar pressure (5801 psi)

técnicas

HPLC: suitable
LC/MS: suitable

L × D.I.

15 cm × 4.6 mm

superficie

200 m2/g

cobertura de la superficie

3.5 μmol/m2

impurezas

<10 ppm metals

Matriz

silica gel, high purity, spherical base material
fully porous particle

grupo activo de la matriz

cyano phase

tamaño de partícula

5 μm

tamaño de poro

180 Å

Intervalo de pH operativo

2-8

aplicaciones

food and beverages

técnica de separación

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Categorías relacionadas

Descripción general

La columna de HPLC Discovery® Cyano se utiliza para la retención y separación de analitos fuertemente básicos, como las sales de amonio cuaternario, con excelentes formas de pico.

Características y beneficios

  • Baja hidrofobicidad para una rápida elución de los analíticos hidrófobos
  • Forma de pico excelente y retención de los analitos fuertemente básicos
  • Retención de las analitos polares
  • Selectividad única
  • Retención significativamente inferior a la C18 (normalmente requiere un menor porcentaje de fase orgánica móvil)
  • Separaciones LC-MS estables y de bajo sangrado
  • Compatible con fases orgánicas muy acuosas

Información legal

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
295280-06
295280-05
295280-04
295280-03
295280-02

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Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

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Fan Zhang et al.
European journal of medicinal chemistry, 46(7), 3149-3157 (2011-04-26)
A series of novel 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives were synthesized and their cytotoxic activity against A549, H460, HT-29 and SMMC-7721 cell lines was evaluated in vitro. Among them, ten compounds (10, 11, 14, 16, 17, 26, 27, 29, 30 and 31) displayed
Thomas J Woltering et al.
Bioorganic & medicinal chemistry letters, 18(3), 1091-1095 (2007-12-22)
A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of a cyano group by a five-membered heterocycle produced compounds inhibiting the binding of [(3)H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both
T A Verdoorn et al.
European journal of pharmacology, 269(1), 43-49 (1994-09-15)
The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown because pharmacological tools that could clearly distinguish between different structural isoforms have not
Ye Ding et al.
Chemical communications (Cambridge, England), 47(33), 9495-9497 (2011-07-19)
A novel and facile DDQ-mediated dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones is described. The formation of lactones proceeds by a radical ion mechanism, which has been established by DPPH˙-mediated chemical identification, ESR spectroscopy
Jun Liang et al.
Journal of medicinal chemistry, 56(11), 4521-4536 (2013-05-15)
Herein we report our lead optimization effort to identify potent, selective, and orally bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropylamide modifications, each of which exhibited improved TYK2 potency and JAK1
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Questions

1–4 of 4 Questions  

  1. ¿Me podrías confirmar que la composición de esta columna es end-capped cyanosilyl silica gel for chromatography R? Gracias!

    1 answer

    1. These columns are end-capped, but the phase is cyanopropyl.

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  4. Please provide the below details for the column Carbon loading%- Pore size- Surface area- pH stability- End capping-

    1 answer

    1. TS Answer:
      - 4.5% Carbon loading
      - Pore size: 180 Å
      - Surface area: 200 m2/g
      - Operating pH range: 2-8
      - Endcapped
      - Particle Size: 5 μm
      - Temperature Range: ≤70 °C
      - Maximum Pressure: 400 bar pressure (5801 psi)
      - Suitable for USP L10

      Helpful?

Reviews

Active Filters

  1. India
    • Review 1
    • Votes 0
    2 out of 5 stars.

    Column to column variation

    Variation in Retention time from column to column observed

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for your review. While minor variability between batches may occur, the degree of difference in retention times would be impacted by run times. Assuming all other conditions are identical, an overall +/- 5% may be possible. As there are a number of variables to consider, we encourage customers who experience problems with our products to call or email us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

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