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Z2626

Sigma-Aldrich

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

Sinónimos:

L-694,599, Squalestatin

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About This Item

Fórmula empírica (notación de Hill):
C35H43O14Na3
Número de CAS:
144541-82-2
Peso molecular:
756.68
MDL number:
MFCD03788025
UNSPSC Code:
12352106
NACRES:
NA.77

product name

Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial

biological source

microbial

Quality Level

200

assay

≥95% (HPLC)

form

lyophilized powder

solubility

DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

shipped in

wet ice

storage temp.

−20°C

Application

Zaragozic acid A trisodium salt has been used as:
  • a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
  • a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
  • a cholesterol synthesis inhibitor in T cells

Biochem/physiol Actions

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Legal Information

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
Griffin S, et al.
Biology of Reproduction, 99(4), 749-760 (2018)
Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5
Sawaya AP, et al.
Test, 293(4), 1439-1449 (2018)
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
So T, et al.
Journal of immunology (Baltimore, Md. : 1950), 186(6), 3547-3555 (2011)
Y Ichinose et al.
Gene, 80(2), 315-323 (1989-08-15)
We have isolated cDNA clones encoding the mouse cytokeratin No. 19 (Ck 19) from an intestinal cDNA library using synthetic oligodeoxyribonucleotides as probes. We obtained four independent clones, which correspond to about 1.4-kb of ck19 cDNA. Nucleotide sequence analysis revealed
Kaitlyn M Dykstra et al.
Oncotarget, 6(39), 41535-41549 (2015-11-26)
Multiple myeloma (MM) is characterized by the production of monoclonal protein (MP). We have shown previously that disruption of the isoprenoid biosynthetic pathway (IBP) causes a block in MP secretion through a disruption of Rab GTPase activity, leading to an
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