SRP3317
ANGPTL-3 human
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinónimos:
ANG-5, ANGPT5
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
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origen biológico
human
recombinante
expressed in CHO cells
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
mol peso
62.0 kDa
envase
pkg of 50 μg
impurezas
endotoxin, tested
color
white to off-white
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... ANGPTL3(27329)
Descripción general
ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain.[1] It is mainly present in the hepatocytes and is also secreted into circulation.[2] The gene is mapped to human chromosome 1p31.[3]
Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) analysis at an apparent molecular weight of 62kDa, and contains 452 amino acid residues including a C-terminal His tag.
Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) analysis at an apparent molecular weight of 62kDa, and contains 452 amino acid residues including a C-terminal His tag.
Acciones bioquímicas o fisiológicas
ANGPTL-3 (Angiopoietin like protein 3) can exert activities related to both angiogenesis and lipid metabolism.[4][5] ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL (high-density lipoprotein)-associated cholesterol.[2] The fibrinogen like portion of the ANGPTL-3 protein can bind α-5/β-3 integrins leading to endothelial cell adhesion and migration.[5] Mutations in this gene can result in familial combined hypobetalipoproteinemia.[1]
Forma física
Lyophilized from 10mM Sodium Phosphate, pH 7.5.
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Dong Zhao et al.
Cardiovascular diabetology, 15(1), 132-132 (2016-09-14)
Angiopoietin-like protein 3 (ANGPTL3) is a major lipoprotein regulator and shows positive correlation with high-density lipoprotein-cholesterol (HDL-c) in population studies and ANGPTL3 mutated subjects. However, no study has looked its correlation with HDL components nor with HDL function in patients
Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study.
Chung HS, et al.
Cardiovascular Diabetology, 15, 1-1 (2016)
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.
Camenisch G, et al.
The Journal of Biological Chemistry, 277, 17281-17281 (2002)
Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.
Oldoni F, et al.
Atherosclerosis, 246, 193-193 (2016)
Mitsuru Ono et al.
The Journal of biological chemistry, 278(43), 41804-41809 (2003-08-12)
Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using deletion mutants of human ANGPTL3, we demonstrated that the N-terminal coiled-coil domain-containing fragment-(17-207) and
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