SRE0013
Interferon Alpha 2A human
recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), lyophilized powder
Sinónimos:
Interferon α 2A human, INFα2A
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About This Item
UNSPSC Code:
41106305
NACRES:
NA.26
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
recombinant
expressed in HEK 293 cells
Quality Level
assay
≥98% (SDS-PAGE)
form
lyophilized powder
storage temp.
−20°C
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General description
IFN-α-2a belongs to the type I interferon protein family. Interferon α 2A is one among the three variants of IFN-α2.[1] Recombinant human IFN-α-2a is expressed in human 293 cells as a glycosylated monomer of 165 amino acids, with an average molecular weight of 20 kDa (monomer).
Application
Interferon α 2A human has been used as an inhibitor of hepatitis D virus (HDV).[2]
Biochem/physiol Actions
Interferon Alpha 2A human is produced by many cell types in response to viral infection. IFN-α-2A has antiproliferative and antitumor activities, as well as induction of apoptosis and inflammatory response
Interferon α 2A might be implicated in the regression of proliferative diabetic retinopathy.[3] Telaprevir and pegylated interferon–α-2a (PEG-IFN–α-2a) serves as a potential therapeutic method for hepatitis C virus (HCV).[1] IFN α 2A along with IFN α 2b and IFN α2c exhibits anti-proliferative effect.[4]
Interferon α 2A might be implicated in the regression of proliferative diabetic retinopathy.[3] Telaprevir and pegylated interferon–α-2a (PEG-IFN–α-2a) serves as a potential therapeutic method for hepatitis C virus (HCV).[1] IFN α 2A along with IFN α 2b and IFN α2c exhibits anti-proliferative effect.[4]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype
Garbe C, et al.
The Journal of Investigative Dermatology, 95-95 (1990)
A screening assay for the identification of host cell requirements and antiviral targets for hepatitis D virus infection.
Bettina B, et al.
Antiviral Research, 141, 116-123 (2017)
Telaprevir and pegylated interferon?alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients.
Tara L K, et al.
Hepatology (2007)
Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype.
Garbe C, et al.
The Journal of Investigative Dermatology, 95(6), 231S-237S (1990)
Interferon alpha-2a for proliferative diabetic retinopathy after complete laser panretinal photocoagulation treatment.
Leibovitch I, et al.
Ophthalmic Surgery, Lasers & Imaging Retina, 35(1), 16-22 (2004)
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