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SML3047

Sigma-Aldrich

Urolithin C

≥97% (HPLC)

Sinónimos:

3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one, 3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one, 3,8,9-Trihydroxyurolithin

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About This Item

Fórmula empírica (notación de Hill):
C13H8O5
Número de CAS:
165393-06-6
Peso molecular:
244.20
MDL number:
MFCD20275232
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C2=CC(O)=C(O)C=C2C3=C(C=C(O)C=C3)O1

Biochem/physiol Actions

Urolithin C is chebulic ellagitannins metabolite that exerts antiproliferative and antioxidant activity. Urolithin C exhibit glucose dependent enhancement of insulin secretion in islet cells under normal or dysfunctional conditions. Apparently, it facilitates L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Inhae Kang et al.
Molecular nutrition & food research, 60(5), 1129-1138 (2016-02-14)
Urolithins (Uro) are ellagic acid (EA)-derived metabolites produced by gut microbes. There is a growing interest in the biological activities of Uro. Our aim was to evaluate the impacts of Uro on regulating triglyceride (TG) accumulation using cultures of primary
Daniil N Olennikov et al.
Nutrients, 7(10), 8456-8477 (2015-10-17)
Chebulic ellagitannins (ChET) are plant-derived polyphenols containing chebulic acid subunits, possessing a wide spectrum of biological activities that might contribute to health benefits in humans. The herbal formulation Padma Hepaten containing ChETs as the main phenolics, is used as a
Xudong Zeng et al.
American journal of translational research, 11(10), 6316-6325 (2019-11-19)
Cardiovascular diseases are the main cause of death and disability among diabetes patients. Atherosclerosis-associated stroke is one of the most severe complications in diabetes patients. DPP-4 inhibitors are a class of potent anti-glycemic agents used to treat diabetes. Recently, some
Morgane Bayle et al.
British journal of pharmacology, 176(20), 4065-4078 (2019-08-06)
The pharmacology of polyphenol metabolites on beta-cell function is largely undetermined. We sought to identify polyphenol metabolites that enhance the insulin-secreting function of beta-cells and to explore the underlying mechanisms. INS-1 beta-cells and rat isolated islets of Langerhans or perfused

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