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SML1554

Sigma-Aldrich

S3QEL 2

Sinónimos:

1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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About This Item

Fórmula empírica (notación de Hill):
C19H25N5
Número de CAS:
890888-12-7
Peso molecular:
323.44
UNSPSC Code:
12352200
NACRES:
NA.77

form

powder

Quality Level

100

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.
S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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