As mentioned on the Product Specification Sheet, this product can be dissolved in warm water ? 2.0 mg/ml. The exact concentration will be listed on the lot specific Certificate of Analysis. A Certificate can be accessed in the DOCUMENTATION section under 'Certificate of Analysis'. Please see the link below:
https://www.sigmaaldrich.com/product/sigma/sml1447#product-documentation
SML1447
Clemizole hydrochloride
≥98% (HPLC)
Sinónimos:
1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride, 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride, 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride, CID 2782 hydrochloride, NSC 46261 hydrochloride
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5 MG
US$ 126,00
25 MG
US$ 506,00
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5 MG
US$ 126,00
25 MG
US$ 506,00
About This Item
Fórmula empírica (notación de Hill):
C19H20ClN3 · HCl
Número de CAS:
Peso molecular:
362.30
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
powder
condiciones de almacenamiento
desiccated
color
white to beige
solubilidad
H2O: 2 mg/mL, clear (warmed)
temp. de almacenamiento
2-8°C
cadena SMILES
ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl
InChI
1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
Clave InChI
DNFMJYXRIMLMBZ-UHFFFAOYSA-N
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Descripción general
Clemizole is a potent anti-allergic drug.[1]
Acciones bioquímicas o fisiológicas
Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.
Clemizole is a potent and preferring inhibitor of TRPC5; Antihistaminic.
Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.[2]
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Clemizole hydrochloride.
Parvez M
Acta Crystallographica Section C, Structural Chemistry, 52(4), 904-905 (1996)
Scott C Baraban et al.
Nature communications, 4, 2410-2410 (2013-09-05)
Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Nav1.1 (SCN1A), a voltage-gated sodium channel. Here we characterize zebrafish Nav1.1 (scn1Lab) mutants
Caoimhin S Griffin et al.
Scientific reports, 8(1), 9264-9264 (2018-06-20)
Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca2+ influx via voltage-gated Ca2+ channels. The cellular mechanisms linking these events are poorly understood, but studies have suggested that activation of TRPC4 channels could
Alberto Arboit et al.
Cells, 9(2) (2020-02-09)
Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information. While synaptic and intrinsic cellular mechanisms of persistent firing have been proposed, underlying cellular mechanisms are not
Katarina Ondrusova et al.
Scientific reports, 7(1), 16332-16332 (2017-11-29)
Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is
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