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Merck
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Documentos clave

SMB00375

Sigma-Aldrich

Nadifloxacin

≥98% (HPLC)

Sinónimos:

Nadifloxacin, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, Acuatim, Jinofloxacin, OPC-7251,   9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid

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About This Item

Fórmula empírica (notación de Hill):
C19H21FN2O4
Número de CAS:
124858-35-1
Peso molecular:
360.38
Código UNSPSC:
51102829
NACRES:
NA.85

origen biológico

synthetic (Organic)

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to yellow

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

DNA synthesis | interferes
enzyme | interferes

temp. de almacenamiento

−20°C

InChI

1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)

Clave InChI

JYJTVFIEFKZWCJ-UHFFFAOYSA-N

Descripción general

Chemical structure: fluoroquinolone
Nadifloxacin is antimicrobial in nature, and is a fluorinated quinolone. It is highly potent against Gram-negative and Gram-positive bacteria, especially Propionibacteruim acnes.[1]

Acciones bioquímicas o fisiológicas

Nadifloxacin is used as a topical antibacterial, which is bactericidal due to its capability of preventing the negative supercoiling of bacterial DNA. DNA supercoiling, replication, transcription are catalyzed by DNA gyrase. In Japan, it is used to treat skin infection and acne.[2] Studies show, that nadifloxacin is capable of successfully treating green nail syndrome (GNS) caused by Pseudomonas aeruginosa.[3]

Almacenamiento y estabilidad

Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510) Non Combustible liquids.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510): Non Combustible Solids

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SLCM0922
SLCJ8331
SLCG8571
SLCG6045
SLCB1036

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Varsha Narayanan et al.
Dermatology and therapy, 4(2), 233-248 (2014-09-13)
Skin and soft tissue infections involve microbial invasion of the skin and underlying soft tissues and are estimated to affect 7-10% of hospitalized patients worldwide. Nadifloxacin, a topical fluoroquinolone, has been shown to be effective against aerobic Gram-negative, Gram-positive (including
Simon Müller et al.
Case reports in dermatology, 6(2), 180-184 (2014-09-10)
Green nail syndrome (GNS) caused by Pseudomonas aeruginosa is the most common bacterial nail infection. The treatment of GNS is challenging in many cases and recommendations based on clinical trials are lacking. We report two cases with GNS successfully treated
Ujwala Shinde et al.
Indian journal of pharmaceutical sciences, 74(3), 237-247 (2013-02-27)
Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the

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